On Saturday, November 5th the Buckeyes will play at home against the Hoosiers of Indiana. Another Big 10 matchup and one that Ohio State has dominated by an overall record of 67-9 with the most recent 38-10 win from last year. OSU has not lost to Indiana since 1988.

Historical Scores for Ohio State vs. Indiana
| Year |
Score |
| 2010 |
W 38-10 |
| 2009 |
W 44-3 |
| 2006 |
W 41-10 |
| 2005 |
W 30-7 |
| 2004 |
W 26-14 |
| 2003 |
W 35-6 |
| 2002 |
W 45-17 |
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