On November 19th, Ohio State will play at home against the Penn St. Nittany Lions. This will be another big game for the Buckeyes with the outcome heavily helping the victor in the Big Ten. Historically, OSU is 14-11 against Penn State and slightly better at home with an 9-5 record.

Historical Scores for Ohio State vs. Penn State
| Year |
Score |
| 2010 |
W 38-14 |
| 2009 |
W 24-7 |
| 2008 |
L 6-13 |
| 2007 |
W 37-17 |
| 2006 |
W 28-6 |
| 2005 |
L 10-17 |
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