On November 12th, Ohio State will play at away against the Purdue Boilmakers at Ross-ade Stadium. Last year, OSU defeated Purdue 49-0. Historically, OSU leads the series 38-13 and also has a 26-6 record against Purdue at home.

Historical Scores for Ohio State vs. Purdue
| Year |
Score |
| 2010 |
W 49-0 |
| 2009 |
L 18-26 |
| 2008 |
W 16-3 |
| 2007 |
W 23-7 |
| 2004 |
L 17-24 |
| 2003 |
W 16-13 |
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